How LIPUS Works: Mechanism of Action
Anasonic’s Low-Intensity Pliant Ultrasound (LIPUS) technology leverages the therapeutic potential of sound waves to stimulate biological responses that promote healing and regeneration. This non-invasive approach is particularly effective in treating chronic kidney disease (CKD) by enhancing kidney function and reducing disease progression.
GFR Improvement
Enhanced Filtration
LIPUS increases the Glomerular Filtration Rate (GFR) by stimulating the function of glomeruli, the filtering units of the kidneys. Improved GFR leads to more efficient waste removal from the blood.
Pressure Regulation
The therapy activates the renal baroreflex, helping to regulate blood pressure and improve overall kidney function. This mechanism is crucial in reducing hypertension, a common complication in CKD patients.
Nephroprotection
Anti-Inflammatory Effects
LIPUS reduces inflammation by modulating immune responses and decreasing the production of pro-inflammatory cytokines. This helps protect kidney tissues from further damage.
Antioxidative Effects
The therapy enhances the activity of antioxidant enzymes, reducing oxidative stress and protecting kidney cells from damage caused by free radicals.
Mechanical Stimulation
Cavitation
LIPUS induces microbubbles in the tissues, which expand and contract with the ultrasound waves. This process, known as cavitation, creates mechanical forces that stimulate cellular activities.
Microstreaming
The oscillation of microbubbles generates fluid movement (microstreaming) around cells, enhancing nutrient and oxygen delivery and waste removal.